Had an issue with trucks not being able to path correctly and not able to get to where they need to go but did not complain about it. Watching the building it showed that items had been reserved to be picked up but a second later it cleared. Same on the receiving end, showed stuff was going to be put it but then 2 seconds later cleared.

Took a while to work out what was going on as no indication as to what the issue was but finally found I had sealed off the receiving unit and the only way in was across the railway line. Once I put a crossing in it worked fine. However it should have had an error that the truck could not get it to the place and it would have taken seconds to work out.

I've noticed this behavior... it's because the pathing system is on a separate thread, so what you're seeing is the data race condition. If you've got a lot of trucks trying to navigate and a very large map, it can take sometimes quite a while for the pathing system to start determining that some trucks have nowhere to go, or that some locations are inaccessible.

That said, I have noticed that having a steady flow of jobs for only some of the trucks on one part of the island can keep any trucks from alarming to an inaccessible storage. I imagine a separate alert for "X storage is inaccessible" might help to point these kinds of issues out more quickly.