The title may be exaggerated, but the issue is real.
The pickups seem to become lazy after I leave my game unattended for a bit. They won't take on transport jobs, whether requests or disposal. I can force them by increasing the priority of requests to 1, but they become lazy again after doing one job. Recovering them back to the depot has the same effect - do one job, then become lazy again. Restarting the game fixes the issue temporarily, but the same thing happens again if I leave the game unattended for a bit. Pickups and trucks assigned to a building or mining seem to not be affected. Doing things like building planning, fiddling with buildings, etc. seem to keep them from becoming lazy (after a game restart or start of the game).
I've read the logs of the game and haven't seen any kind of errors related to jobs. I found 2 or 3 errors related to simulation, but is not relevant to the job issue.
I don't know at what point in the game progress this issue started happening, but I noticed that I keep on ordering pickups because vehicle management keeps on saying that the vehicles are extremely busy.
I have no idea why this happens. I properly noticed this issue the other day when I was just letting the game simulate to recover spent materials. After a day of testing, I decided to report this as a bug.
Please, anyone, let me know if this is fixable.

For context, I have these mods installed:
- AutoForestryDesignations vAutoForestryDesignations
- AutoTerrainDesignations vAutoTerrainDesignations
- Bagger288Mod vBagger288Mod
- boost-plus-plus vboost-plus-plus
- CAP-PierWall-LiquidDump vCAP-PierWall-LiquidDump
- CAP-PierWall-SeawaterPump vCAP-PierWall-SeawaterPump
- CargoHelicopter vCargoHelicopter
- gameplay-plus-plus vgameplay-plus-plus
- GridBattery vGridBattery
- keybind-framework vkeybind-framework
- PierWallMod vPierWallMod
- PipeTerrainIgnoreMod vPipeTerrainIgnoreMod
- procedural-research-tree vprocedural-research-tree
- ProgramableNetwork vProgramableNetwork
- recipes-plus-plus vrecipes-plus-plus
- speed-plus-plus vspeed-plus-plus
- tweaks-plus-plus vtweaks-plus-plus
- UndergroundTransportMod vUndergroundTransportMod
- utilities-plus-plus vutilities-plus-plus
- WindPower vWindPower
- worldgen-plus-plus vworldgen-plus-plus
After setting it back to "Passive", the clump of lazy pickups started to disperse and find jobs. After observing for a while without doing anything, they have completely gotten rid of their "laziness". Though they may have been cured, a side effect has been left on my island: some buildings with active import and export requests have become "stale," so I have to reconfigure them so that the pickups can take on their requests again.